Mechanism · 4 records
Glymphatic transport
Sleep-active cerebrospinal fluid dynamics support metabolite clearance
family: Sleep
ND-0093 · 2025 · Experimental neuroscience study
Norepinephrine-mediated slow vasomotion drives glymphatic clearance during sleep
Hauglund et al. Cell
Synchronized norepinephrine and vascular oscillations were linked to glymphatic CSF flow during NREM sleep; zolpidem dampened key dynamics.
ND-0094 · 2026 · Randomized crossover human study
The glymphatic system clears amyloid beta and tau from brain to plasma in humans
Dagum et al. Nature Communications
Normal sleep was associated with morning plasma biomarker patterns consistent with greater glymphatic clearance of amyloid beta and tau than sleep deprivation.
ND-0095 · 2012 · Foundational animal study
A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid beta
Iliff et al. Science Translational Medicine
Established a paravascular pathway supporting exchange of CSF with interstitial fluid and clearance of solutes.
ND-0125 · 2026 · Closed-loop stimulation experiment
Closed-loop auditory stimulation in phase with slow waves during sleep enhances cerebrospinal fluid flow in humans
Levitt, Zeng, Yang, Jacob & Lewis. Science Translational Medicine
Short pink-noise bursts delivered at slow-wave peaks increased slow waves and caused larger CSF flow waves. The effect depended on phase: sound that missed the peak did not produce it. Widespread hemodynamic waves followed the stimulus.