ND-0663 · 2013 · Theory or framework
Sleep drives metabolite clearance from the adult brain
Xie L et al. Science. 2013.
doi.org/10.1126/science.1241224 · Summary not yet checked against the text
Source details checked refers to publication information or an official source page. See the record’s limitations for incomplete extraction and the method for how to read the labels.
What the source reports
In mice, interstitial space expanded by about 60% during sleep and clearance of amyloid beta roughly doubled compared with waking.
Limitations
Animal mechanism; human evidence arrived in 2025-26 (ND-0093, ND-0094).
Field
Sleep and brain clearance
Notes and follow-up
Added from the Corpus Desk (card xie-2013-sleep-clearance) on 2026-11-09. Evidence strength and translation distance not yet rated. WELL label held for review.
indexed under
Field
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